Botox vs. Xeomin for Frown Lines: What’s the Difference?

Botox and Xeomin are both popular options for softening frown lines, and they’re often mentioned in the same breath. If you’re trying to decide between them, here’s a general overview of how they compare, and why Xeomin is the option we reach for most.

This article is for general informational purposes and isn’t a substitute for a consultation. Your provider will determine what’s right for you based on your goals, history, and facial anatomy.

What Causes Frown Lines?

The vertical lines between your eyebrows, often called “11 lines,” form over time from repeated facial movement, like frowning, squinting, or concentrating. Treatments like Botox and Xeomin work by temporarily relaxing the muscles behind that movement, so the skin above smooths out.

What Is Botox?

Botox is the most widely recognized name in this category of treatment, the way “Kleenex” gets used for tissues. Most patients start to notice results within several days, with results generally settling in over the following one to two weeks and typically requiring treatment every 3-4 month. 

What Is Xeomin?

Xeomin works in a similar way to Botox. The main difference people ask about is the formula: Xeomin is manufactured without the additional proteins found in Botox, which is why it’s sometimes called a “purified” or “naked” formula. Timing and duration are generally comparable to Botox for most patients.

Botox vs. Xeomin: How They Compare

FactorBotoxXeomin
FormulaIncludes additional stabilizing proteinsPurified to include only the active ingredient
TimingVisible results within about a week; lasts a few monthsVisible results within about a week; lasts a few months
StorageRequires refrigeration before useDoes not require refrigeration before use
CostPricing depends on units neededPricing depends on units needed (generally comparable)

We don’t think one of these as universally “better” they work in largely the same way. But when patients ask what we personally recommend at The Skin Specialist, Xeomin is usually it, mainly because we like the simplicity of its more purified formula and to reduce the risk of resistance, especially for patients who plan to make this a regular part of their routine. Also, it’s a great option for those wanting to maintain a natural-appearing result.

What to Expect During Treatment

Treatment starts with a consultation where we get to know your goals and take a look at your specific facial movement. The injections themselves take just a few minutes. Most patients go right back to their day afterward with some minor restrictions. Results build in gradually over the following week or two. Then you will see your wrinkles start to soften and your skin look smoother. Many patients love this treatment because it even makes their makeup look better since it doesn’t accentuate lines.

Frequently Asked Questions About Botox

Not universally, they work in similar ways and produce similar results for most people. The formula is the main difference, and it matters more to some patients than others.

Results generally last a similar amount of time for both, though this varies person to person. Your provider can talk through what to expect at your consultation.

Yes, many patients do. We’ll go over your treatment history together and figure out the right approach for you.

 This depends on your goals and how your specific muscles move. We determine this together during your in-person consultation.

Ready to Talk Through Your Options?

Not sure whether Botox or Xeomin is the right fit for your frown lines? Schedule a consultation with The Skin Specialist in Claremont, and we’ll build a plan based on you, not a one-size-fits-all answer.

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The Skin Specialist | 452 Auto Center Drive, Claremont, CA 91711 | (909) 228-3185

Do you treat patients from outside Claremont? Yes. The Skin Specialist regularly sees patients from Pomona, Upland, La Verne, San Dimas, Ontario, Rancho Cucamonga, Diamond Bar, and other communities across the Inland Empire and Los Angeles.

Important Disclosure

The information provided in this article is based on general knowledge and not on specific sources. Consultation with a qualified dermatologist or skin care professional is recommended for personalized advice. This article is for informational purposes only and is not a substitute for professional medical advice. Always consult with a qualified healthcare provider for guidance on your specific skin concerns.